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Chronect DBS
Autosampler™

Instead of punching blood spots the DBS Autosampler™ uses clamps and dried blood spots or dried matrix spots which are directly desorbed as a liquid sample for analysis. This enables a completely automated workflow for DBS analysis. Dried blood spot (DBS) sampling is an emerging technology for bioanalysis offering easy, convenient and cost-effective sample collection, transport and storage.

Features

Chronect DBS
Autosampler™

  • Unique Flow-through desorption (FTD™) technology for sample prep and optional online coupling to (SPE)-(LC)-MS/MS
  • Option for mounting different clamp sizes for the desorption of different sized spots
  • Partial spot or full spot desorption
  • Automated internal standard addition (AISA™)
  • HotCap™ heated capillary for better desorption
  • Wash flow path with solvents and/or HotCap™
  • Standard 96 DBS card capacity:4 sample spots per card allows possibility of 384 samples

Working principle

No manual intervention required with our innovative patented technology. Direct elution of DBS from cards enables optional online clean-up and analyte separation by SPE prior to analysis in an automated workflow. Replaceable clamp head sizes of 2, 4, 6 or 8 mm clamp and seal filter paper cards up to pressures of about 200 bar (up to 100 bar for the 8 mm clamp). Desorption solvent is delivered by a high pressure dispenser (HPD™).

Specifications

  • Flow-through desorption concept (FTD™): Leak-tight clamp heads provide direct elution of DBS from cards without punching discs.
  • Desorption methods: Partial spot, full spot
  • Clamp heads Replaceable: sizes 2 mm, 4 mm, 6 mm and 8 mm available. SS316. Leak-tight up to 200 bar for 2 mm, 4 mm and 6 mm clamp heads. Leak-tight up to 100 bar for 8 mm clamp head.
  • Sample capacity: 4 spot Whatman or PerkinElmer type DBS card in a cassette format, with an extended capacity of up to 96 DBS cards, 384 samples.
  • Intelligent Vision Camera (IVC™) Camera designed to provide: missing card detection, accurate positioning of DBS cards in the clamp, 1D and 2D sample barcode identification, full or partial spot desorption options, full image capture for sample information storage, tracking and traceability.
  • Internal standard loop: 20 μL

Applications

Methylmalonic acid；Glutathione (biomarker for autism)；Immunosuppressant drugs；Anabolic steroid esters in cattle；Fentanyl and analoges；TDM of nortriptyline；Opioids for pain management；Nicotine and metabolites；Antimalaria drugs